EFFECT OF VITAMIN D TAKEN IN PATIENTS WITH HPV-ASSOCIATED CERVICAL DISEASES
N.V. Zarochentseva, L.K. Jijihia
For quotation:
Zarochentseva N.V., Dzhidzhikhia L.K. The effect of vitamin D intake in patients with HPV-associated
diseases of the cervix. Questions of practical colposcopy. Genital infections. 2022; (4): 17–23.
DOI 10.46393/27826392_2022_4_17
Annotation:
Vitamin D is one of the significant components involved in the regulation of calcium-phosphorus metabolism,
innate and acquired immunity, antitumor protection and many other body functions. Hypovitaminosis D is associated with the risk of developing diseases of the cardiovascular, endocrine, digestive, respiratory and reproductive systems, malignant neoplasms and immune disorders. The article provides a review of publications devoted to the study of the effect of vitamin D deficiency on the course of cervical intraepithelial neoplasia. The results of our own study on the use of effective therapeutic doses of vitamin D depending on the concentration of vitamin D in the blood serum in HPV-associated cervical diseases are described.
The purpose of the study was to determine the level of vitamin D in blood serum in HPV-associated cervical diseases of varying severity before taking vitamin D and 6 months after drug correction.
Material and methods. A search was carried out for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) over the past 2–15 years. The review included articles from the peer-reviewed literature. In order to identify deficiency and insufficiency of vitamin D, 305 patients aged 18 to 55 years with histologically confirmed diagnoses were examined: 80/305 (26.2%) patients with HPV-associated cervicitis, 120/305 (39.3%) – with LSIL, 70/305(22.9%) – with HSIL, 35/305 (11.6%) women with relapses after excisional therapy for HSIL.
Results. Severe vitamin D deficiency was observed in 2/70 (2.9%) and 1/35 (2.9%) of women with HSIL and recurrences after excisional treatment, respectively. Vitamin D deficiency was detected in 14/80 (17.5%) patients with HPV-associated chronic cervicitis, in 37/120 (30.7%) women with LSIL, in 20/70 (28.6%) and 3/ 35 (8.6%) patients had HSIL and recurrence after excisional treatment, respectively. Vitamin D deficiency was found in the majority of patients in all groups, especially in 70/120 (58.3%) women with LSIL and 44/70 (62.8%) with HSIL. Normal vitamin D levels were determined mainly in patients with HPV-associated cervicitis – 39/80 (48.8%). At the end of treatment, there was an increase in 25(OH)D concentrations, no significant deficiency, and a significant decrease in vitamin D deficiency in the groups of patients with LSIL, HSIL, and relapses who received 10,000 and 8,000 IU, respectively.
Conclusion. In order to prevent HPV-associated neoplastic changes in the cervix, it is necessary to maintain a sufficient level of 25(OH)D in the blood serum for the functional activity of the antiviral immune system. Preference should be given to colecalciferol due to more efficient conversions into active metabolites of vitamin D. The results of such studies can become one of the strong arguments in favor of its use in the general prevention program for cervical cancer, especially in women of reproductive age.
Journal “Issues of practical colposcopy. Genital infections" No. 4_2022
https://drive.google.com/file/d/1KfrNz5T3--Xwk1nZeQh6ACliastp3pV-/view
N.V. Zarochentseva, L.K. Jijihia
For quotation:
Zarochentseva N.V., Dzhidzhikhia L.K. The effect of vitamin D intake in patients with HPV-associated
diseases of the cervix. Questions of practical colposcopy. Genital infections. 2022; (4): 17–23.
DOI 10.46393/27826392_2022_4_17
Annotation:
Vitamin D is one of the significant components involved in the regulation of calcium-phosphorus metabolism,
innate and acquired immunity, antitumor protection and many other body functions. Hypovitaminosis D is associated with the risk of developing diseases of the cardiovascular, endocrine, digestive, respiratory and reproductive systems, malignant neoplasms and immune disorders. The article provides a review of publications devoted to the study of the effect of vitamin D deficiency on the course of cervical intraepithelial neoplasia. The results of our own study on the use of effective therapeutic doses of vitamin D depending on the concentration of vitamin D in the blood serum in HPV-associated cervical diseases are described.
The purpose of the study was to determine the level of vitamin D in blood serum in HPV-associated cervical diseases of varying severity before taking vitamin D and 6 months after drug correction.
Material and methods. A search was carried out for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) over the past 2–15 years. The review included articles from the peer-reviewed literature. In order to identify deficiency and insufficiency of vitamin D, 305 patients aged 18 to 55 years with histologically confirmed diagnoses were examined: 80/305 (26.2%) patients with HPV-associated cervicitis, 120/305 (39.3%) – with LSIL, 70/305(22.9%) – with HSIL, 35/305 (11.6%) women with relapses after excisional therapy for HSIL.
Results. Severe vitamin D deficiency was observed in 2/70 (2.9%) and 1/35 (2.9%) of women with HSIL and recurrences after excisional treatment, respectively. Vitamin D deficiency was detected in 14/80 (17.5%) patients with HPV-associated chronic cervicitis, in 37/120 (30.7%) women with LSIL, in 20/70 (28.6%) and 3/ 35 (8.6%) patients had HSIL and recurrence after excisional treatment, respectively. Vitamin D deficiency was found in the majority of patients in all groups, especially in 70/120 (58.3%) women with LSIL and 44/70 (62.8%) with HSIL. Normal vitamin D levels were determined mainly in patients with HPV-associated cervicitis – 39/80 (48.8%). At the end of treatment, there was an increase in 25(OH)D concentrations, no significant deficiency, and a significant decrease in vitamin D deficiency in the groups of patients with LSIL, HSIL, and relapses who received 10,000 and 8,000 IU, respectively.
Conclusion. In order to prevent HPV-associated neoplastic changes in the cervix, it is necessary to maintain a sufficient level of 25(OH)D in the blood serum for the functional activity of the antiviral immune system. Preference should be given to colecalciferol due to more efficient conversions into active metabolites of vitamin D. The results of such studies can become one of the strong arguments in favor of its use in the general prevention program for cervical cancer, especially in women of reproductive age.
Journal “Issues of practical colposcopy. Genital infections" No. 4_2022
https://drive.google.com/file/d/1KfrNz5T3--Xwk1nZeQh6ACliastp3pV-/view
