LOW GRADE SQUAMOUS INTRAEPITHELIAL LESION: POSSIBILITIES OF CYTOKINE THERAPY
I.I. Kutsenko, I.O. Borovikov, E.I. Kravtsova, S.K. Batman, A.A. Avakimyan, M.I. Biryukova, Kh.I. Gorring
For quotation:
Kutsenko I.I., Borovikov I.O., Kravtsova E.I. etc. Low degree of squamous cell
intraepithelial lesions: possibilities of cytokine therapy. Practical questions
colposcopy. Genital infections. 2022; (4): 30–35.
DOI 10.46393/27826392_2022_4_30
Annotation:
The article presents the experience of treating patients with low-grade cervical intraepithelial lesions (LSIL/CIN I) associated with human papillomavirus (HPV), including local application of recombinant interleukin-2 (rIL-2), with an assessment of clinical and microbiological effectiveness.
The purpose of the study is to determine the comparative effectiveness of complex treatment of patients with low-grade cervical squamous intraepithelial lesion (LSIL) using a recombinant interleukin-2 drug along with excisional therapy.
Material and methods. A comparative one-year analysis of the treatment of two groups of patients with low-grade cervical intraepithelial lesions was carried out: the first group (n = 40) - radio wave loop excision of the cervix, the second group (n = 37) - excision and the use of the drug recombinant interleukin-2 (Roncoleukin). Colposcopy, cytohistological examination of cervical biopsy samples, Pap test, PCR of high carcinogenic risk HPV (HCR) were used.
Results and conclusion. Experience in complex therapy and follow-up for a year of women diagnosed with mild cervical dysplasia; low degree of squamous intraepithelial lesions (LSIL/CIN I)”, receiving a local drug of recombinant interleukin-2, showed its high clinical (normalization of the colposcopic picture - 94.6%, histologically confirmed absence of LSIL in cervical biopsies - 91.9%) and microbiological (PCR negativity of HPV HCR – 78.4%) efficiency.
Journal “Issues of practical colposcopy. Genital infections" No. 4_2022
https://drive.google.com/file/d/1KfrNz5T3--Xwk1nZeQh6ACliastp3pV-/view
I.I. Kutsenko, I.O. Borovikov, E.I. Kravtsova, S.K. Batman, A.A. Avakimyan, M.I. Biryukova, Kh.I. Gorring
For quotation:
Kutsenko I.I., Borovikov I.O., Kravtsova E.I. etc. Low degree of squamous cell
intraepithelial lesions: possibilities of cytokine therapy. Practical questions
colposcopy. Genital infections. 2022; (4): 30–35.
DOI 10.46393/27826392_2022_4_30
Annotation:
The article presents the experience of treating patients with low-grade cervical intraepithelial lesions (LSIL/CIN I) associated with human papillomavirus (HPV), including local application of recombinant interleukin-2 (rIL-2), with an assessment of clinical and microbiological effectiveness.
The purpose of the study is to determine the comparative effectiveness of complex treatment of patients with low-grade cervical squamous intraepithelial lesion (LSIL) using a recombinant interleukin-2 drug along with excisional therapy.
Material and methods. A comparative one-year analysis of the treatment of two groups of patients with low-grade cervical intraepithelial lesions was carried out: the first group (n = 40) - radio wave loop excision of the cervix, the second group (n = 37) - excision and the use of the drug recombinant interleukin-2 (Roncoleukin). Colposcopy, cytohistological examination of cervical biopsy samples, Pap test, PCR of high carcinogenic risk HPV (HCR) were used.
Results and conclusion. Experience in complex therapy and follow-up for a year of women diagnosed with mild cervical dysplasia; low degree of squamous intraepithelial lesions (LSIL/CIN I)”, receiving a local drug of recombinant interleukin-2, showed its high clinical (normalization of the colposcopic picture - 94.6%, histologically confirmed absence of LSIL in cervical biopsies - 91.9%) and microbiological (PCR negativity of HPV HCR – 78.4%) efficiency.
Journal “Issues of practical colposcopy. Genital infections" No. 4_2022
https://drive.google.com/file/d/1KfrNz5T3--Xwk1nZeQh6ACliastp3pV-/view
